陈万涛

　　医学博士、博士生导师;是新世纪百千万人才工程xxx人选、上海市(第三期)重点学科带头人和上海市优秀学科带头人。现任上海市口腔医学研究所所长、附属第九人民医院口腔颌面外科系和口腔颌面-头颈肿瘤科行政副主任。美国得克萨斯大学 M.D安德森癌症中心胸/头颈肿瘤科客座教授。兼任中华医学会口腔生物医学专业委员会副主任委员，上海市口腔医学会口腔基础专业委员会主任委员;是《口腔生物医学》副主编。

　　主攻研究方向为口腔颌面部-头颈肿瘤诊断和靶向治疗基础和临床研究和口腔颅颌面部遗传性疾病研究。主持包括国家自然科学基金重点项目、重大研究计划(培育)项目的xxx课题8项，主持国际合作和上海市重点项目8项。近年发表专业SCI论文40多篇;申请国家和国际专利7项，主编专著和教材4部;获省、部和市局级科技8项，其中第1完4项。先后荣获特殊津贴、上海市银蛇、明治乳业生命科学优秀，上海市医务职工科技创新新人和科技创新标兵，上海交通大学医学院特殊贡献等荣誉称号。

　　 研究方向

　　口腔颌面部-头颈肿瘤诊断和靶向治疗基础和临床研究，口腔颅颌面部遗传性疾病诊治研究。

　　 出诊信息

　　每周二(全天)

　　 教育经历

　　1981.9-1986.7 青岛大学医学院(原青岛医学院)大学本科;

　　1993.9-1998.6 上海交通大学医学院(原上海第二医科大学)硕博连读;

　　2007.5-2008.11 美国大学MD安德森肿瘤中心 高级访问学者

　　 工作经历

　　1986.8-1993.8山东泰山医学院附属医院口腔科医师

　　1998.7-1999.8上海交通大学医学院附属第九人民医院口腔颌面外科主治医师

　　1999.8-2003.6上海交通大学医学院附属第九人民医院口腔颌面外科副主任医师、副教授

　　1999.10-至今 附属第九人民医院口腔颌面外科肿瘤生物学实验室主任

　　2001.1-至今 上海交通大学口腔医学院口腔临床免疫教研室主任

　　2004.12-至今 上海市口腔医学重点实验室常务副主任、博士生导师

　　2005.11-至今 上海交通大学医学院附属第九人民医院口腔颌面外科 研究员

　　2008.8-至今 上海交通大学医学院附属第九人民医院口腔颌面外科系行政副主任

　　2008.9-至今 上海交通大学医学院口腔医学院口腔基础教研室副主任

　　2009.11-至今 上海市(第三期)重点学科带头人(口腔基础医学)上海交通大学医学院教授

　　2012.3-至今 上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科行政副主任

　　2012.12-至今 上海口腔医学研究所所长

　　 科研

　　主持包括1项国家自然科学基金重点项目、1项国家自然科学基金重大研究计划(培育)项目、6项国家自然科学基金面上项目，主持3项国际合作研究项目、2项上海市纳米专项、3项上海市重点基础项目;获省、部级科技6项，其中第1完3项。专业发表SCI论文40多篇。主编专著和教材4、副主编1部、参编6部。

　　 学术兼职

　　中华口腔医学会口腔生物医学专业委员会副主任委员，上海市口腔医学会口腔基础医学专业委员会主任委员;还兼任国际口腔颌面外科医师协会、国际分析细胞学协会、美国肿瘤研究学会(AACR)、美国医学遗传学会(ASHG)会员。是《口腔生物医学》副主编，Head and Neck Oncology, Chinese Journal Dental Research、《中华口腔医学》、《中国口腔颌面外科》等10本专业的编委。

　　 获情况

　　1. 口腔癌基因表达谱和诊治靶点基因的基础和临床，2012年度(第十一届)上海医学科技二等，陈万涛(第1完)

　　2.口腔黏膜上皮细胞体外癌变模型的建立及基因组学、蛋白质组学研究，2014教育部高等学校优秀自然科学二等，陈万涛(第7完)

　　3. 口腔颌面部鳞癌诊断和治疗靶点的基础与临床应用, 2014教育部高等学校优秀自然科学二等, 陈万涛(第1完)

　　4. 口腔颌面部癌靶向生物治疗和化疗的基础及临床研究，2006年上海市科学技术进步三等,陈万涛(第1完).

　　5. 高危型人乳头状瘤病毒与口腔粘膜癌变的相关性研究, 2005年教育部提名国家科学技术(自然科学)二等,陈万涛(第7完).

　　6. 口腔鳞癌顺铂耐药相关基因表达谱鉴定及靶向CCND1/cLAP1/XIAP的增敏效果, 2014中华口腔医学会科技三等, 陈万涛(第2完)

　　 主要论文

　　1. Xiao M, Wang X, Chen W*. The clinical translational potential of p53-relatedalterations as cancer biomarkers. Histol Histopathol. 2015, 12:11637.

　　2. Zhang J,Qin X,Sun Q,Guo H, Wu X, Xie F,Xu Q, Yan M,Liu J,Han Z and Chen W*. Transcriptional control of PAX4-regulated miR-144/451 modulates metastasis by suppressing ADAMs expression. Oncogene. 2015, 34(25):3283- 3295.

　　3. Cui Z, Song L, Hou Z, Han Y, Hu Y, Wu Y, Chen W, Mao L*. PLU-1/JARID1B overexpression predicts proliferation properties in head and neck squamous cell carcinoma. Oncol Rep. 2015, 33(5):2454-2460.

　　4. Lv Z, Wu X, Cao W, Shen Z, Wang L, Xie F, Zhang J, Ji T, Yan M, Chen W*. Parathyroid hormone-related protein serves as a prognostic indicator in oral squamous cell carcinoma. J Exp Clin Cancer Res. 2014,18:33:100. doi: 10.1186/s13046-014-0100-y

　　5.Pan J, Wang T, Wang L, Chen W*, Song M*. Cyclic strain-induced cytoskeletal rearrangement of human periodontal ligament cells via the Rho signaling pathway. PLOS ONE. 2014, 11;9(3):e91580. doi: 10.1371/journal.pone.0091580

　　6. Yu J, Deng H, Xie F, Chen W, Zhu B*, Xu Q*. The potential of pH-responsive PEG-hyperbranched polyacylhydrazone micelles for cancer therapy. Biomaterials. 2014,35(9):3132-3144

　　7. Yu J, Xie F, Bao X, Chen W*, Xu Q*. miR-300 inhibits epithelial to mesenchymal transition and metastasis by targeting Twist in human epithelial cancer. Mol Cancer. 2014,24;13:121

　　8. Wang L, Pan J, Wang T, Song M*, Chen W*. Pathological cyclic strain-induced apoptosis in human pathological cyclic strain-induced apoptosis in human caspase-3/PARP pathway. PLOS ONE. 2013, 8(10): e75973. doi:10.1371/journal.pone.0075973.

　　9. Deng R, Wang X, Lv Y, Yan M, Hanada S, Xu Q, Zhang J, Han Z, Chen W*, Zhang P*. A new gamboge derivative Compound 2 inhibits cancer stem-like cells via suppressing EGFR tyrosine phosphorylation in head and neck squamous cell carcinoma. J Cell Mol Med. 2013, 17(11):1422-1433.

　　10. Wu X, Cao W, Wang X, Zhang J, Lv J, Qin X, Wu Y, Chen W*. TGM3, a candidate tumor suppressor gene, contributes to human head and neck cancer. Mol Cancer. 2013, 12(1):151. doi: 10.1186/1476-4598-12-151

　　11. Song X, Xia R, Li J, Long Z, Ren H, Chen W, Mao L*. Common and complex Notch1 mutations in Chinese oral squamous cell carcinoma. Clin Cancer Res, 2013, 1;20(3):701-10. doi: 10.1158/1078-0432.CCR-13-1050

　　12. Liu J, Wang X, Liu P, Deng R, Lei M, Chen W*, Hu L*. 20(S)-Protopanaxadiol (PPD) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs. Bioorg Med Chem. 2013,15;21(14):4279-4287.

　　13. Yan M, Yang X, Wang L, David C, Ye D, Chen W*, Zhang P*. Plasma membrane proteomics of tumor spheres identify CD166 as a novel marker for cancer stem-like cells in head and neck squamous cell carcinoma. Mol Cell Proteomics. 2013,12(11):3271-3284.

　　14. Cui Z, Cao W, Li J, Song X, Mao L*, Chen W*. TRIM24 overexpression is common in locally advanced head and neck squamous cell carcinoma and correlates with aggressive malignant phenotypes. PLOS ONE. 2013,8(5):e63887.

　　15. Zuo J, Huang X, Zhong X, Zhu B, Sun Q, Jin C, Quan H, Tang Z *, Chen W *. A comparative study of the influence of three pure titanium plates with different micro- and nanotopographic suces on preosteoblast behaviors. J Biomed Mater Res A. 2013 ,101(11):3278-3284

　　16. Xu Q, Sun Q, Zhang J, Yu J, Chen W*, Zhang Z*. Downregulation of miR-153 contributes to epithelial-mesenchymal transition and tumor metastasis in human epithelial cancer. Carcinogenesis. 2013,34(3):539–549.

　　17. Sun Q, Zhang J, Cao W, Wang X, Xu Q, Yang M, Wu X, Chen W*. Dysregulated miR-363 affects head and neck cancer invasion and metastasis by targeting podoplanin. Int J Biochem Cell Biol. 2013,45:513-520.

　　18. Wang X, Deng R, Lv Y, Xu Q, Yang M, Ye D, Chen W*. Gambogic acid as a non-competitive inhibitor of ATP-Binding cassette transporter B1 reverses the multidrug resistance of human epithelial cancers by promoting ATP-Binding cassette transporter B1 protein degradation. Basic Clin Pharmacol Toxicol. 2013,112(1):25-33

　　19. Wang X, Chen W*. Gambogic acid is a novel anti-cancer agent that inhibits cell proliferation. angiogenesis and metastasis. Anticancer Agents Med Chem. 2012,12(8):994-1000

　　20. Feng Z, Xu Q, Chen W*. Epigenetic and genetic alterations-based molecular classification of head and neck cancer. Expert Rev Mol Diagn. 2012,12(3):279–290.

　　21. Zhang J, Sun Q, Zhang J, Ge SF Han Z, Chen W*. Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop. Oncogene. 2013,32(1):61-69.

　　22. Cao W, Feng Z, Cui Z, Zhang C, Sun Z, Li M, Chen W*. Up-regulation of enhancer of zeste homolog 2 ss associated positively with cyclin D1 overexpression and poor clinical outcome in head and neck squamous cell carcinoma. Cancer. 2012,118(11):2858-2871.

　　23. Feng Z, Guo W, Zhang C, Xu Q, Zhang P, Sun J, Zhu H, Wang Z, Li J, Wang L, Wang B, Ren G, Ji T, Tu W, Yang X, Qiu W, Mao L, Zhang Z*, Chen W*. CCND1 as a predictive biomarker of neoadjuvant chemotherapy in patients with locally advanced head and neck squamous cell carcinoma. PLOS ONE. 2011,6(10):e26399.

　　24. Wang X, Lv Y, Shen G, Chen W*. One germline mutation of PTCH gene in a Chinese mily with non-syndromic keratocystic odontogenic tumours. Int J Oral Maxilloc Surg. 2011 ,40(8):829-833.

　　25. Cao W, Younis R, Li J, Chen H, Xia R, Li M, Chen W*, Ren H*. EZH2 promotes malignant phenotypes and is a predictor of oral cancer development in patients with oral leukoplakia. Cancer Prev Res. 2011,4(11):1816-1824.

　　26. Song M, Xiao C, Wang T, Pei Q, Wang S, Xu L, Chen W*. Study of the differentially expressed genes in pleomorphic adenoma using cDNA microarrays. Pathol Oncol Res. 2011,17(3):765-769.

　　27. Zhang T, Chen M, Lu Y, Xing Q*, Chen W*. A novel mutation of the PTCH1 gene activates the Shh/Gli signaling pathway in a Chinese mily with nevoid basal cell carcinoma syndrome. Biochem Biophys Res Commun. 2011,409(2):166-170

　　28. Zhang J, Cao W, Xu Q, Chen W*. The expression of EMP1 is downregulated in oral squamous cell carcinoma and possibly associated with tumour metastasis. J Clin Pathol. 2011,64(1):25-29.

　　29. Yan M, Wang L, Zuo H, Zhang Z, Chen W, Mao L and Zhang P*. HH/GLI signalling as a new therapeutic target for patients with oral squamous cell carcinoma. Oral Oncol. 2011, 4(6)7:504-509.

　　30. Xu Q, Liu X, Chen W, Zhang Z*. Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference. J Transl Med. 2010,8:136. doi: 10.1186/1479-5876-8-136

　　31. Cao W, Zhang Z, Xu Q, Sun Q, Yan M, Zhang J, Zhang P, Han Z, Chen W*. Epigenetic silencing of MAL, a putative tumor suppressor gene, can contribute to human epithelial cell carcinoma. Mol Cancer, 2010, 9:296 doi:10.1186/1476-4598-9-296.

　　32. Zhang J, Guo H*, Qian G, Ge S, Ji H, Hu X, Chen W. MiR-145, a new regulator of the DNA Fragmentation Factor-45 (DFF45)-mediated apoptotic network. Mol Cancer, 2010, 9:211.

　　33. Yan M, Xu Q, Zhang P, Zhou X, Zhang Z, Chen W*. Correlation of NF-kappaB signal pathway with tumor metastasis of human head and neck squamous cell carcinoma. BMC Cancer, 2010, 10:437.

　　34. Xu Q, Liu X, Cai Y, Yu Y*, Chen W*. RNAi-mediated ADAM9 gene silencing inhibits metastasis of adenoid cystic carcinoma cells. Tumour Biol. 2010,31(3):217-224

　　35. Lu Y，Zhou H, Chen W, Zhang Y，Hamburger A*. The ErbB3 binding protein EBP1 regulates ErbB2 protein levels and tamoxifen sensitivity in breast cancer cells. Breast Cancer Res Treat. 2011,126(1):27-36

　　36. He D, Xu Q, Zhang P, Yan M, Zhou X, Zhang Z，Chen W*. The NF-kappa B inhibitor celastrol could enhance the anti-cancer effect of Gambogic acid on oral squamous cell carcinoma. BMC Cancer. 2009, 9:343doi:10.1186/1471-2407-9-343.

　　37. Xu Q, Chen W, Wang Z, Zheng J, Zhang Z*. Mice transgenic with SV40-late-promoter-driven polyomavirus middle T oncogene exclusively develop hemangiomas. Transgenic Res. 2009, 18(3):399-406.

　　38. Zhang P, Zhang Y, Mao L, Zhang Z, Chen W*. Side population in oral squamous cell carcinoma possesses tumor stem cell phenotypes. Cancer Lett. 2009, 277(2):227-234.

　　39. Zhou X, Zhang Z, Yang X, Chen W*, Zhang P*. Inhibition of cyclin D1 expression by cyclin D1 shRNAs in human oral squamous cell carcinoma cells is associated with increased cisplatin chemosensitivity. Int J Cancer. 2009;124(2):483-489.

　　40. Xu Q, Zhang Z, Zhang P, Chen W*. Antisense oligonucleotides and all-trans retinoic acid have a synergistic anti-tumor effect on oral squamous cell carcinoma. BMC Cancer. 2008,8;159.doi:10.1186/14712407-8-159.

　　41. Lv Y, Zhu H,Ye W, Zhang M, He D, Chen W*. A new germline mutation of PTCH gene in a Chinese mily with nevoid basal cell carcinoma syndrome. Chin Med J. 2008,121(2):118-121.

　　42. Yu Y, Chen W, Zhang Y, Hamburger A, Pan H, Zhang Z*. Suppression of salivary adenoid cystic carcinoma growth and metastasis by ErbB3 Binding protein Ebp1 transfer. Int J Cancer. 2007,120(9):1909-1913.

　　43. Jiang C, Ye D, Qiu W, Zhang X, Zhang Z, He D, Zhang Z, Chen W*. Response of lymphocyte subsets and cytokines to Shenyang prescription in Sprague-Dawley rats with tongue squamous cell carcinomas induced by 4NQO. BMC Cancer. 2007,7:40.

　　44. Zhang B*, Guan C, Chen W*, Zhang P, Yan M, Shi J, Qin C, Yang Q. A20 inhibits human salivary adenoid cystic carcinoma cells invasion via blocking nuclear ctor-κB activation. Chin Med J. 2007,120(20):1830-1835.(*通讯作者)

　　 著作译作

　　1.主编:陈万涛. 《口腔临床免疫学实验技术》;上海交通大学出版社，2009年，29万字

　　2.主编:陈万涛. 《口腔临床免疫学》;上海交通大学出版社，2010年，56万字

　　10.Chief in Editor: Shree Ram Singh. Stem Cell, Regenerative Medicine and Cancer;Nova Science Publishers, Inc.2010,(参编6万字:陈万涛)

　　3.主编:王松灵.《口腔生物学与口腔实验动物模型》;人民卫生出版社，2011年，(参编11万字:陈万涛)

　　4.Chief in Editor: Wantao Chen. Fundamentals of Oral Biomedicine; SCIENCE PRESS, 2014

　　5.主编:陈万涛. 《口腔颌面头颈部肿瘤生物学》;上海交通大学出版社，2015年